Diabetes mellitus (DM) has been known as
one of the main universal health difficulties. Conferring to the estimated, 382
million people suffering from this disease, which is an amount equal to 8.3% of
the population and Type 2 diabetes making up about 90% of the cases(1,
2).Trace elements display a central task
in the suitable functioning of carbohydrate and lipid metabolism by various
mechanism(3,
4). Vanadium is a group 3d transition metal that occurs in the
humans as a micronutrient and performances as an inorganic cofactor in many
enzymatic reactions, having and assisting cellular bioactivities(5-7). Primary
attention to varied biological actions of vanadium focused on
anti-diabetic activities but has shifted to anti-cancer and anti-parasitic
drugs(7,
8).Vanadyl sulfate has
been used in humans as insulin-mimetic salt and thus controls both type 1 and
type 2 DM. Vanadyl sulfate defends the beta cells of Islets of Langerhans thus endorsing
insulin production and discharge, leading to improved blood sugar regulation(9-11). On the other hand some studies
found that vanadium is not effective against hyperglycemic states to the extent
shown by some other researchers. Another recent study shows that vanadium is
not effective against Diabetes mellitus at all(12).

There
are also different opinions about the effect of vanadium on insulin. Some
believe that vanadium increases insulin secretion, but others believe that this
element increases the sensitivity of insulin, rather than increasing its
secretion(13,
14).

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Due
to the rising occurrence of diabetes especially type 2 diabetes, multiform study
intended at aborting and remedy is one of the universal investigate priorities.
The present study was designed because of conflicting results regarding the
effect of vanadium on metabolic profiles. To the best of our facts, this is the
first study to evaluate a new modified method for induction of type 2 diabetes
in rats and so to estimate vanadyl sulfate effect on PPAR-? and TNF-? gene
expression and so related metabolic responses, simultaneously, in vivo.